When it comes to antonyms for the phrase "most well-suited," there are several possibilities depending on your intended meaning. For example, if you're looking for a word that suggests a lack of suitability or compatibility, you might consider "ill-matched," "inappropriate," or "unsuitable." Alternatively, if you're looking for a word that suggests something that's simply not the best fit, you might choose "suboptimal," "inferior," or "inadequate." Other possible antonyms could include "mismatched," "incongruous," or "inapplicable," depending on the context in which you're using the phrase "most well-suited.